the association between rheumatoid arthritis and periodontal disease类风湿性关节炎和牙周疾病之间的联系.pdf

Detert et al. Arthritis Research Therapy 2010, 12:218 /content/12/5/218 R E V I E W The association between rheumatoid arthritis and periodontal disease 1 2 1 1 Jacqueline Detert , Nicole Pischon , Gerd R Burmester and Frank Buttgereit* resistance factors of the host (risk factors and immune Abstract status) are crucial for the progression of the periodontal Chronic, plaque-associated inl ammation of the gingiva destruction (Figure 1). PD has been proposed as having and the periodontium are among the most common an etiologic or modulating role in cardiovascular and oral diseases. Periodontitis (PD) is characterized by cerebrovascular disease, diabetes, and respiratory disease the inl ammatory destruction of the periodontal and adverse pregnancy outcome, and several mechanisms attachment and alveolar bone, and its clinical have been proposed to explain or support such theories. appearance can be inl uenced by congenital as well Moreover, oral lesions are indicators of disease progres- as acquired factors. The existence of a rheumatic or sion, and the oral cavity can be a window to overall health other inl ammatory systemic disease may promote and body systems. In recent years, remarkable epi- PD in both its emergence and progress. However, demiological and pathological relationships between there is evidence that PD maintains systemic diseases. periodontal diseases and rheumatic