comparative transcriptome analyses of deltamethrin-resistant and -susceptible anopheles gambiae mosquitoes from kenya by rna-seq比较转录组分析deltamethrin-resistant和易感rna-seq来自肯尼亚的冈比亚按蚊.pdf

Comparative Transcriptome Analyses of Deltamethrin- Resistant and -Susceptible Anopheles gambiae Mosquitoes from Kenya by RNA-Seq 1 2 2,4 3 1 Mariangela Bonizzoni *, Yaw Afrane , William Augustine Dunn , Francis K. Atieli , Goufa Zhou , 1 5 2 1 Daibin Zhong , Jun Li , Andrew Githeko , Guiyun Yan 1 Program in Public Health, University of California Irvine, Irvine, California, United States of America, 2 Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya, 3 Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, United States of America, 4 Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America, 5 Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, United States of America Abstract Malaria causes more than 300 million clinical cases and 665,000 deaths each year, and the majority of the mortality and morbidity occurs in sub-Saharan Africa. Due to the lack of effective vaccines and wide-spread resistance to antimalarial drugs, mosquito control is the primary method of malaria prevention and control. Currently, malaria vector control relies on the use of insecticides, primarily pyrethroids. The extensive use of insecticides has imposed strong selection pressures for resistance in the mosquito populations. Consequently, resistance to pyrethroids in Anopheles gambiae, the main malaria vector in sub-Saharan Africa, has become a major obstacle for malaria control. A key element of resistance management is the identi