apolipophorin-iii mediates antiplasmodial epithelial responses in anopheles gambiae (g3) mosquitoes在冈比亚疟蚊apolipophorin-iii介导antiplasmodial上皮反应(g3)蚊子.pdf

Apolipophorin-III Mediates Antiplasmodial Epithelial Responses in Anopheles gambiae (G3) Mosquitoes 1¤. 2. 2 2 1¤ 2 Lalita Gupta , Ju Young Noh , Yong Hun Jo , Seung Han Oh , Sanjeev Kumar , Mi Young Noh , Yong 3 4 5 2 2 1 Seok Lee , Sung-Jae Cha , Sook Jae Seo , Iksoo Kim , Yeon Soo Han *, Carolina Barillas-Mury * 1 Mosquito Immunity and Vector Competence Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America, 2 Department of Agricultural Biology, College of Agriculture and Life Science, Chonnam National University, Gwangju, South Korea, 3 Department of Parasitology, College of Medicine and Frontier Inje Research for Science and Technology, Inje University, Busan, Korea, 4 Johns Hopkins School of Public Health, Department of Molecular Microbiology and Immunology and Malaria Research Institute, Baltimore, Maryland, United States of America, 5 Division of Applied Life Science, Gyeongsang National University, Jinju, Korea Abstract Background: Apolipophorin-III (ApoLp-III) is known to play an important role in lipid transport and innate immunity in lepidopteran insects. However, there is no evidence of involvement of ApoLp-IIIs in the immune responses of dipteran insects such as Drosophila and mosquitoes. Methodology/Principal Findings: We report the molecular and functional characterization of An. gambiae apolipophorin-III (AgApoLp-III). Mosquito ApoLp-IIIs have diverged extensively from those