the early responses of vegf and its receptors during acute lung injury implication of vegf in alveolar epithelial cell survival的早期反应vegf及其受体在急性肺损伤影响vegf的肺泡上皮细胞的生存.pdf

Available online /content/10/5/R130 Vol 10 No 5 Open Access Research The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival Marco Mura, Bing Han, Cristiano F Andrade, Rashmi Seth, David Hwang, Thomas K Waddell, Shaf Keshavjee and Mingyao Liu Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network; Department of Surgery, Faculty of Medicine, University of Toronto, 200 Elizabeth Street, Toronto, Canada M5G 2C4 Corresponding author: Mingyao Liu, mingyao.liu@utoronto.ca Received: 3 Jun 2006 Revisions requested: 21 Jun 2006 Revisions received: 17 Jul 2006 Accepted: 13 Sep 2006 Published: 13 Sep 2006 Critical Care 2006, 10:R130 (doi:10.1186/cc5042) This article is online at: /content/10/5/R130 © 2006 Mura et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The function of the vascular endothelial growth and alveolar epithelial cell death. In the BAL, VEGF was factor (VEGF) system in acute lung injury (ALI) is controversial. significantly increased in both sham and IIR groups, while the We hypothesized that the role of VEGF in ALI may depend upon VEGF and VEGF receptor (VEGFR)-1 in the lung tissues were the stages of pathogenesis of ALI. significantly reduced in these two groups. The increase of VEGF