the cellular prion protein prpc is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins细胞的朊病毒蛋白prpc参与上皮细胞的增殖和junction-associated蛋白的分布.pdf

The Cellular Prion Protein PrPc Is Involved in the Proliferation of Epithelial Cells and in the Distribution of Junction-Associated Proteins 1,2,3.¤a ´ 1,2,3.¤b 4 1,2,3 Etienne Morel , Stephane Fouquet , Carine Strup-Perrot , Cathy Pichol Thievend , 1,2,3 5 1,2,3 1,2,3 Constance Petit , Damarys Loew , Anne-Marie Faussat , Lucile Yvernault , Martine Pinc¸on- Raymond1,2,3, Jean Chambaz1,2,3¤c, Monique Rousset1,2,3, Sophie Thenet1,2,3¤c, Caroline Clair1,2,3* ´ ´ 1 Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie-Paris 6, UMR S 872, Paris, F-75006 France, 2 INSERM, U 872, Paris, F-75006 France, 3 Universite Paris ´ Descartes-Paris 5, UMR S 872, Paris, F-75006 France, 4 Radiosensibilite des tissus sains, UPRES EA 27.10, Institut Gustave Roussy PRI, Villejuif F-94805, France, 5 Laboratoire ´ ´ de Spectrometrie de Masse Proteomique, Institut Curie, Pavillon Pasteur, 75248 Paris, France Abstract c Background: The physiological function of the ubiquitous cellular prion protein, PrP , is still under debate. It was essentially studied in nervous syst