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Available online /content/8/4/R130 Vol 8 No 4 Open Access Research article Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis 1 1 1 2 1 Anne R Kinderlerer , Rivka Steinberg , Michael Johns , Sarah K Harten , Elaine A Lidington , 1 2 1 Dorian O Haskard , Patrick H Maxwell and Justin C Mason 1Cardiovascular Medicine Unit, Eric Bywaters Center for Vascular Inflammation, Imperial College London, Hammersmith Hospital, London, UK 2The Renal Unit, Imperial College London, Hammersmith Hospital, London, UK Corresponding author: Justin C Mason, justin.mason@imperial.ac.uk Received: 30 Jan 2006 Revisions requested: 21 Mar 2006 Revisions received: 3 Jul 2006 Accepted: 21 Jul 2006 Published: 21 Jul 2006 Arthritis Research Therapy 2006, 8:R130 (doi:10.1186/ar2019) This article is online at: /content/8/4/R130 © 2006 Kinderlerer et al., licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Hypoxia, which leads to dysfunctional cell metabolism, and protein expression in hypoxia was associated with an increase in complement activation both play central roles in the steady-state mRNA. L-Mevalonate and geranylgeraniol reversed pathogenesis of r