cytotoxic terpene quinones from marine sponges从海绵中细胞毒性萜醌类.pdf
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Mar. Drugs 2010, 8, 2849-2870; doi:10.3390/md8122849
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Review
Cytotoxic Terpene Quinones from Marine Sponges
Marina Gordaliza
Department of Pharmaceutical Chemistry, Pharmacy Faculty, Salamanca University, Campus Miguel
de Unamuno, 37007 Salamanca, Spain; E-Mail: mliza@usal.es; Tel.: +34-923-294-528;
Fax: +34-923-294-515
Received: 7 October 2010; in revised form: 12 November 2010 / Accepted: 17 November 2010 /
Published: 24 November 2010
Abstract: The 1,4-benzoquinone moiety is a common structural feature in a large number
of compounds that have received considerable attention owing to their broad spectrum of
biological activities. The cytotoxic and antiproliferative properties of many natural
sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such
as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising
opportunities for the development of new antitumor agents. The present review
summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and
their bioactive analogues and derivatives.
Keywords: terpene quinone; terpene hydroquinone; avarone; avarol; cytotoxicity
1. Introduction
The few therapeutic novelties of synthetic origin that have appeared on the pharmaceutical market,
of which more than 88% are based on preexisting structures, have flooded the pharmaceutical world
with very similar products. This has led to a new and enthusiastic retrospective appraisal o
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