cytotoxic sesterterpenoids from a sponge hippospongia sp.细胞毒性sesterterpenoids海绵hippospongia sp。.pdf

Mar. Drugs 2012, 10, 987-997; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp. Yu-Chia Chang 1,2, Shang-Wei Tseng 1,3, Li-Lian Liu 4,5, Yalan Chou 4, Yuan-Shing Ho 6, Mei-Chin Lu 1,3 and Jui-Hsin Su 1,3,5,* 1 National Museum of Marine Biology Aquarium, Pingtung 944, Taiwan; E-Mails: jay0404@ (Y.-C.C.); fallboys2006@ (S.-W.T.); jinx6609@.tw (M.-C.L.) 2 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan 3 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 4 Institute of Marine Biology, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails: lilian@.tw (L.-L.L.); ylchou@ (Y.C.) 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 6 Eastern Marine Biology Research Center, Fisheries Research Institute, Taitung 961, Taiwan; E-Mail: yuanho18@ * Author to whom correspondence should be addressed; E-Mail: x2219@.tw; Tel.: +886-8-8825001 (ext. 3126); Fax: +886-8-8825087. Received: 28 March 2012; in revised form: 18 April 2012 / Accepted: 24 April 2012 / Published: 27 April 2012 Abstract: One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these