cyclic bis-1,3-dialkylpyridiniums from the sponge haliclona sp.循环bis-1,3-dialkylpyridiniums海绵haliclona sp。.pdf

Mar. Drugs 2012, 10, 2126-2137; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp. 1 1 1 2 3 Yoonyeong Lee , Kyoung Hwa Jang , Ju-eun Jeon , Woo-Young Yang , Chung J. Sim , Ki-Bong Oh 2,* and Jongheon Shin 1,* 1 Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56 -1, Sillim, Gwanak, Seoul 151-742, Korea; E-Mails: zizel18@snu.ac.kr (Y.L.); khjang@ (K.H.J.); mirabn@snu.ac.kr (J.-e.J.) 2 Department of Agricultural Biotechnology, College of Agriculture Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea; E-Mail: yang0829@snu.ac.kr 3 Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea; E-Mail: cjsim@hnu.kr * Authors to whom correspondence should be addressed; E-Mails: ohkibong@snu.ac.kr (K.-B.O.); shinj@snu.ac.kr (J.S.); Tel.: +82-2-880-4646 (K.-B.O.); +82-2-880-2484 (J.S.); Fax: +82-2-873-3112 (K.-B.O.); +82-2-762-8322 (J.S.). Received: 12 July 2012; in revised form: 9 August 2012 / Accepted: 14 September 2012 / Published: 24 September 2012 Abstract: Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds