biochemical trade-offs evidence for ecologically linked secondary metabolism of the sponge oscarella balibaloi生态与次生代谢的生化权衡证据海绵oscarella balibaloi.pdf

Biochemical Trade-Offs: Evidence for Ecologically Linked Secondary Metabolism of the Sponge Oscarella balibaloi 1,2 2 1 ´ 3 1 ´ Julijana Ivanisevic , Olivier P. Thomas , Laura Pedel , Nicolas Penez , Alexander V. Ereskovsky , Gerald 3 ´ 1 Culioli , Thierry Perez * ´ ´ ´ ´ ´ 1 Universite de la Mediterranee, Centre d’Oceanologie de Marseille, Aix-Marseille Universite, CNRS UMR 6540 DIMAR, Station Marine d’Endoume, Marseille, France, ´ ´ ˆ 2 Universite de Nice-Sophia Antipolis, Laboratoire de Chimie des Molecules Bioactives et des Aromes, CNRS UMR 6001, Institut de Chimie de Nice, Parc Valrose, Nice, ´ France, 3 Universite du Sud Toulon-Var, Laboratoire MAPIEM, EA 4323, La Garde, France Abstract Secondary metabolite production is assumed to be costly and therefore the resource allocation to their production should be optimized with respect to primary biological functions such as growth or reproduction. Sponges are known to produce a great diversity of secondary metabolites with powerful biological activities that may explain their domination in some hard substrate communities both in terms of diversity and biomass. Oscarella balibaloi (Homoscleromorpha) is a recently described, highly dynamic species, which often overgrows other sessile marine invertebrates. Bioactivity measurements (standardized Microtox assay) and metabolic fingerprints were used as indicators of the baseline variations of the O. balibaloi secondary