synthesis and bioactivity of secondary metabolites from marine sponges containing dibrominated indolic systems从海绵中合成和生物活性的次生代谢产物含有dibrominated indolic系统.pdf

Molecules 2012, 17, 6083-6099; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated Indolic Systems Adriano Mollica 1,*, Marcello Locatelli 1, Azzurra Stefanucci 2 and Francesco Pinnen 1 1 Via dei Vestini 31, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University “G. d’ Annunzio” of Chieti-Pescara, Chieti 66100, Italy 2 Piazzale Aldo Moro 5, Department of Organic Chemistry, Faculty of Chemistry, University of Rome “La Sapienza”, Roma 00197, Italy * Author to whom correspondence should be addressed; E-Mail: a.mollica@unich.it; Tel.: +39-085-355-4476; Fax: +39-085-355-4477. Received : 20 April 2012; in revised form: 14 May 2012 / Accepted: 15 May 2012 / Published : 21 May 2012 Abstract: Marine sponges. (e.g., Hyrtios sp., Dragmacidin sp., Aglophenia pleuma , Aplidium cyaneum , Aplidium meridianum .) produce bioactive secondary metabolites involved in their defence mechanisms. Recently it was demonstrated that several of those compounds show a large variety of biological activities against different human diseases with possible applications in medicinal chemistry and in pharmaceutical fields, especially related to the new drug development process. Researchers have focused their attention principally on secondary metabolites with anti-cancer and cytotoxic activities. A common target