synthesis and antiviral bioactivity of chiral thioureas containing leucine and phosphonate moieties合成和抗病毒生物活性的手性硫脲含有亮氨酸和膦酸酯半个.pdf

Molecules 2010, 15, 5112-5123; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antiviral Bioactivity of Chiral Thioureas Containing Leucine and Phosphonate Moieties Jingzi Liu 1,2, Song Yang 1,*, Xiangyang Li 1, Huitao Fan 1, Pinaki Bhadury 1, Weiming Xu 1, Jian 1 1 Wu and Zhencao Wang 1 State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China; E-Mails: liujingz@126.com (J.L.); michael.lee1983@ (X.L.); fanhuitao0818@ 163.com (H.F.); bhadury@ (P.B.); xuweiming2009@163.com(W.X); jianwu2691@(J.W); wzc.4884@163.com (Z.W) 2 Laboratory of Medicinal Chemistry, Zunyi Medical College, Zunyi, 563003, China * Author to whom correspondence should be addressed; E-Mail: gdjhzx@; Tel.: +86 851 362 0521; Fax: +86 851 362 2211. Received: 18 June 2010; in revised form: 26 July 2010 / Accepted: 27 July 2010 / Published: 29 July 2010 Abstract: A series of novel chiral thioureas 3a-n bearing leucine and phosphonate moieties were synthesized in excellent yields. The structures of the compounds were completely characterized by elemental analysis, IR, 1H-, 13C-, 31P- and 19F-NMR spectral data. A half-leaf method was used to determine the in vivo protective and curative efficacies of the title products against tobacco mosaic virus (TMV). The comp