cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol细胞毒性的半合成衍生物elatol isoobtusol.pdf
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Mar. Drugs 2012, 10, 2254-2264; doi:10.3390/m
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Article
Cytotoxic Activity of Semi-Synthetic Derivatives of Elatol
and Isoobtusol
Karen L. Lang 1,*, Izabella T. Silva 1, Lara A. Zimmermann 1, Cíntia Lhullier 1,
2 2 1 1
Maria V. Mañalich Arana , Jorge A. Palermo , Miriam Falkenberg , Cláudia M. O. Simões ,
1 2
Eloir P. Schenkel and Fernando J. Durán
1 Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis,
SC, 88040-970, Brazil; E-Mails: izabellathais@ (I.T.S.); lalinhazi@ (L.A.Z.);
clhullier@.br (C.L.); miriam@ccs.ufsc.br (M.F.); claudias@reitoria.ufsc.br (C.M.O.S.);
eloirschenkel@ (E.P.S.)
2 Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, C1428EGA,
Argentina; E-Mails: vmanalich@qo.fcen.uba.ar (M.V.M.A.); palermo@qo.fcen.uba.ar (J.A.P.);
fduran@qo.fcen.uba.ar (F.J.D.)
* Author to whom correspondence should be addressed; E-Mail: karenluise@;
Tel.: +55-48 Fax: +55-48
Received: 1 August 2012; in revised form: 12 September 2012 / Accepted: 1 October 2012 /
Published: 18 October 2012
Abstract: In the present study, the in vitro cytotoxic effects of six semi-synthetic
derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were
performed on the hydroxyl groups aiming to get
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