糖化血红蛋白在妊娠期糖尿病诊断及监控中的临床价值.doc
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糖化血红蛋白在妊娠期糖尿病诊断及监控中的临床价值
曹玉君 李世莹 张秀枝(通讯作者)
(广州市越秀区妇幼保健院 广东广州 510000)
【摘要】目的 研究糖化血红蛋白(HbA1c)检测应用于诊断、治疗及控制妊娠期糖尿病的临床价值,为妊娠期糖尿病的早期临床诊治提供参考依据。方法 将100例确诊为妊娠期糖尿病的孕妇作为观察组,并选取100例健康的孕妇作为对照组,两组均采集空腹静脉血2ml,应用糖化血红蛋白仪及相关配套试剂检测HbA1c,应用葡萄糖氧化酶法检测空腹血糖(FBG)。结果 观察组FBG和HbA1c均明显高于对照组(P均lt;0.05)。结论 HbA1c检测具有敏感、快速、简便、准确等优点,在妊娠期糖尿病的诊断及监测方面有很高的应用价值。
【关键词】 糖化血红蛋白 妊娠期糖尿病 空腹血糖
【中图分类号】R714.256 【文献标识码】A 【文章编号】2095-1752(2013)32-0124-02
Glycated hemoglobin in gestational diabetes diagnosis and monitoring the clinical value
CAO yu jun,LI shi ying Corresponding author ZHANG xiu zhi
(Yuexiu District of Guangzhou City Maternal and Child Health Hospital 510000, P. R. China)
【Astract】 Objective: Research glycated hemoglobin (HbA1c) detection used in diagnosis, treatment and control gestational diabetes clinical value for gestational diabetes early clinical diagnosis and treatment of provide a reference basis. Methods: 100 cases were diagnosed as gestational diabetes of pregnant women as observation group, and select 100 cases healthy pregnant women as control group, two groups are acquisition hollow venous blood 2 ml, applied glycated hemoglobin instrument and related auxiliary reagent HbA1c test, the application of glucose oxidase method to detect fasting blood glucose (FBG). Results:The observation group FBG and HbA1c were significantly higher than those in the control group (P lt; 0.05). Conclusions: HbA1c test is sensitive, rapid, simple, accurate and advantages, gestational diabetes in the diagnosis and monitoring has high application value.
【Key words】 Glycated hemoglobin Gestational diabetes Fasting plasma glucose
妊娠期糖尿病 ( gestational diabetes mellitus,GDM) 是妊娠期常见的合并症之一。GDM的发生率世界各国报道1%~14%,我国发生率1%~5%,近年有明显升高的趋势。糖尿病孕妇的临床经过复杂,对母儿均有较大危害,必须引起重视[1]。美国糖尿病学会( American Diabetes Associ-ation,ADA) 2011年制定了新的GDM诊断标准。
孕24~28 周用75g 葡萄糖进行口服葡萄糖耐量试验( oral glucose tolerance test,OGTT),以空腹、服糖后1h和2h血糖值5.1/10.0/8.
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