structural basis for the regulation mechanism of the tyrosine kinase capb from staphylococcus aureus酪氨酸激酶的结构依据监管机制变动从金黄色葡萄球菌.pdf

PLoS BIOLOGY Structural Basis for the Regulation Mechanism of the Tyrosine Kinase CapB from Staphylococcus aureus 1[ 1[ 2 1 2¤ Vanesa Olivares-Illana , Philippe Meyer , Emmanuelle Bechet , Virginie Gueguen-Chaignon , Didier Soulat , 3 4 5 2 ´ 3 1 Sylvie Lazereg-Riquier , Ivan Mijakovic , Josef Deutscher , Alain J. Cozzone , Olivier Laprevote , Solange Morera , 2* 1* Christophe Grangeasse , Sylvie Nessler ´ ´ ´ 1 Laboratoire d’Enzymologie et Biochimie Structurales, CNRS, Gif sur Yvette, France, 2 Institut de Biologie et Chimie des Proteines, CNRS, Universite Lyon 1, Universite de Lyon, Lyon, France, 3 Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France 4 Center for Microbial Biotechnology, BioCentrum, Technical University of Denmark, Lyngby, Denmark, 5 Laboratory of Microbiology and Molecular Genetics, AgroParisTech, CNRS, INRA, Thiverval-Grignon, France Bacteria were thought to be devoid of tyrosine-phosphorylating enzymes. However, several tyrosine kinases without similarity to their eukaryotic counterparts have recently been identified in bacteria. They are involved in many physiological processes, but their accurate functions remain poorly understood due to slow progress in their structural characterization. They have been best characterized as copolymerases involved in the