biogeography and virulence of staphylococcus aureus生物地理学和金黄色葡萄球菌的毒力.pdf

Biogeography and Virulence of Staphylococcus aureus 1. 1. 3 1 1 1 1 Juan Fan , Min Shu , Ge Zhang , Wei Zhou , Yongmei Jiang , Yu Zhu , Guihua Chen , Sharon J. 5 1 2,3,4 6 Peacock , Chaomin Wan *, Wubin Pan *, Edward J. Feil * 1 Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan, the People’s Republic of China, 2 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, the People’s Republic of China, 3 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China, 4 Crown Bioscience, Inc. (Beijing), Light Muller Building, ChangPing Science Park, Beijing, the People’s Republic of China, 5 Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom, 6 Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom Abstract Background: Staphylococcus aureus is commonly carried asymptomatically in the human anterior nares and occasionally enters the bloodstream to cause invasive disease. Much of the global diversity of S. aureus remains uncharacterised, and is not clear how disease propensity varies between strains, and between host populations. Methodology: We compared 147 isolates recovered from five kindergartens in Chengdu, China, with 51 isolates contemporaneously recovered from cases of pediatric infection from the main hospital serving this community. The samples were characterised by MLST, the presence/absence of PVL, and antibiotic resistance profiling