staphylococcus aureus and chronic airway disease金黄色葡萄球菌和慢性呼吸道疾病.pdf

INVITED REVIEW Staphylococcus aureus and Chronic Airway Disease Lara Derycke, PhD, Claudina Pe´rez-Novo, PhD, Koen Van Crombruggen, PhD, Marie-Noe¨lle Corriveau, MD,* and Claus Bachert, PhD, MD 27.3%, respectively, whereas 63.6% of all subjects with Abstract: Staphylococcus aureus (S. aureus) is correlated with the 3 CRSwNP were colonized with S. aureus. By analysis of development of persistent severe inflammatory disease of the upper biopsies of sinus mucosa from CRS patients, it was also airway including chronic rhinosinusitis with nasal polyps. This found that the presence of bacterial biofilm was increased inflammation of the upper airways is characterized by a T-helper 4 compared with control patients. Biofilms are formed when 2–driven disease: interleukin-5 is significantly increased and local bacteria adhere to surfaces in an aqueous environment and production of immunoglobulin E is observed. S. aureus and its begin to excrete a slimy, gluelike substance that can anchor enterotoxins are deregulating the tissue inflammation at different