biocompatibility of niobium coatings生物相容性的铌涂料.pdf

Coatings 2011, 1, 72-87; doi:10.3390/coatings1010072 OPEN ACCESS coatings ISSN 2079-6412 /journal/coatings/ Article Biocompatibility of Niobium Coatings René Olivares-Navarrete 1 , Jhon Jairo Olaya 2 , Claudia Ramírez 3 and Sandra Elizabeth Rodil 3,* 1 Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; E-Mail: rene.olivares-navarrete@ 2 Unidad de Materiales, Departamento de Ingeniería Mecánica y Mecátronica, Avenida 30 No. 45-03, Ciudad Unversitaria, Bototá D.C., Colombia; E-Mail: jjolaya@.co 3 Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito exterior SN, Ciudad Universitaria, 04510 México DF, México; E-Mail: claudin90@ * Author to whom correspondence should be addressed; E-Mail: ser42@iim.unam.mx; Tel.: +52 55 Fax: +52-55 Received: 2 August 2011; in revised form: 1 September 2011 / Accepted: 15 September 2011 / Published: 22 September 2011 Abstract: Niobium coatings deposited by magnetron sputtering were evaluated as a possible surface modification for stainless steel (SS) substrates in biomedical implants. The Nb coatings were deposited on 15 mm diameter stainless steel substrates having an average surface roughness of 2 µm. To evaluate the biocompatibility of the coatings three different in vitro tests, using human alveolar bone derived cells, were performed: cellular adhesion, proliferation and viability. Stainless steel substrates and tissue cul