biocompatibility of different nerve tubes生物相容性不同的神经导管.pdf

Materials 2009, 2, 1480-1507; doi:10.3390/ma2041480 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Biocompatibility of Different Nerve Tubes Felix Stang 1,*, Gerburg Keilhoff 2 and Hisham Fansa 3 1 Department of Plastic, Reconstructive and Hand Surgery, University of Luebeck, 23538 Luebeck, Germany 2 Institute of Biochemistry and Cell Biology, University of Magdeburg, 39120 Magdeburg, Germany; E-Mail: gerburg.keilhoff@med.ovgu.de 3 Department of Plastic, Reconstructive and Aesthetic Surgery, Hand Surgery, Klinikum Bielefeld- Mitte, 33604 Bielefeld, Germany; E-Mail: hisham.fansa@klinikumbielefeld.de * Author to whom correspondence should be addressed; E-Mail: felix.stang@gmx.de; Tel.: +49-451-5002061; Fax: +49-451-5002190. Received: 27 August 2009; in revised form: 24 September 2009 / Accepted: 25 September 2009 / Published: 30 September 2009 Abstract: Bridging nerve gaps with suitable grafts is a major clinical problem. The autologous nerve graft is considered to be the gold standard, providing the best functional results; however, donor site morbidity is still a major disadvantage. Various attempts have been made to overcome the problems of autologous nerve grafts with artificial nerve tubes, which are “ready-to-use” in almost every situation. A wide range of materials have been used in animal models but only few have been applied to date clinically, where biocompatibility is an inevitable prerequisite. This review gives an idea about artific