biocompatibility of chitosan carriers with application in drug delivery生物相容性的壳聚糖载体在药物传输中的应用.pdf

J. Funct. Biomater. 2012, 3, 615-641; doi:10.3390/jfb3030615 OPEN ACCESS Journal of Functional Biomaterials ISSN 2079-4983 /journal/jfb/ Review Biocompatibility of Chitosan Carriers with Application in Drug Delivery Susana Rodrigues 1,†, Marita Dionísio 1,†, Carmen Remuñán López 2 and Ana Grenha 1,* 1 Centre for Molecular and Structural Biomedicine (CBME), Institute for Biotechnology and Bioengineering (IBB), Faculty of Sciences and Technology, University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal; E-Mails: susananasus@ (S.R.); maritadionisio@ (M.D.) 2 Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, Santiago de Compostela 15782, Spain; E-Mail: mdelcarmen.remunan@usc.es * Author to whom correspondence should be addressed; E-Mail: amgrenha@ualg.pt; Tel.: +351-289-800-100 (ext. 7441); Fax: +351-289-818-419. † These authors contributed equally to this work. Received: 26 June 2012; in revised form: 3 August 2012 / Accepted: 21 August 2012 / Published: 17 September 2012 Abstract: Chitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and