surface hydrophobic modification of fifth-generation hydroxyl-terminated poly(amidoamine) dendrimers and its effect on biocompatibility and rheology表面疏水改性的第五代端羟基聚(amidoamine)树枝状分子及其对生物相容性的影响和流变学.pdf

Materials 2009, 2, 883-902; doi:10.3390/ma2030883 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Surface Hydrophobic Modification of Fifth-Generation Hydroxyl-Terminated Poly(amidoamine) Dendrimers and Its Effect on Biocompatibility and Rheology Paul D. Hamilton 1,2, Donghui Z. Jacobs 2, Brian Rapp 2 and Nathan Ravi 2,3,4,* 1 Research Branch, Department of Veterans Affairs Medical Center JC 151, 915 N. Grand Blvd. St. Louis, MO 63106, USA; E-Mail: Hamilton@ (P.H.) 2 Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8096, 660 S. Euclid, St. Louis, MO 63110, USA; E-Mails: zhanggloria@ (D.J.); rappb1@ (B.R.) 3 Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, MO 63130, USA 4 Executive Branch, Department of Veterans Affairs Medical Center JC 151, 915 N. Grand Blvd. St. Louis, MO 63106, USA * Author to whom correspondence should be addressed; E-Mail: Nathan.Ravi@; Tel. +1-314 747-4464; Fax: +1-314 289-7009 Received: 25 June 2009; in revised form: 24 July 2009 / Accepted: 31 July 2009 / Published: 4 August 2009 Abstract: Water-soluble, commercially-available poly(amidoamine) (PAMAM) dendrimers are highly-branched, well-defined, monodisperse macromolecules having an ethylenediamine core and varying surface functional groups. Dendrimers are being employed in an increasing number of biomedical applications. In this study, commercially obtained generation 5 hydroxyl-terminated (G