surface hydrophobic modification of fifth-generation hydroxyl-terminated poly(amidoamine) dendrimers and its effect on biocompatibility and rheology表面疏水改性的第五代端羟基聚(amidoamine)树枝状分子及其对生物相容性的影响和流变学.pdf
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Materials 2009, 2, 883-902; doi:10.3390/ma2030883
OPEN ACCESS
materials
ISSN 1996-1944
/journal/materials
Article
Surface Hydrophobic Modification of Fifth-Generation
Hydroxyl-Terminated Poly(amidoamine) Dendrimers and Its
Effect on Biocompatibility and Rheology
Paul D. Hamilton 1,2, Donghui Z. Jacobs 2, Brian Rapp 2 and Nathan Ravi 2,3,4,*
1 Research Branch, Department of Veterans Affairs Medical Center JC 151, 915 N. Grand Blvd. St.
Louis, MO 63106, USA; E-Mail: Hamilton@ (P.H.)
2 Department of Ophthalmology and Visual Sciences, Washington University School of Medicine,
Box 8096, 660 S. Euclid, St. Louis, MO 63110, USA; E-Mails: zhanggloria@ (D.J.);
rappb1@ (B.R.)
3 Department of Energy, Environmental and Chemical Engineering, Washington University in St.
Louis, MO 63130, USA
4 Executive Branch, Department of Veterans Affairs Medical Center JC 151, 915 N. Grand Blvd. St.
Louis, MO 63106, USA
* Author to whom correspondence should be addressed; E-Mail: Nathan.Ravi@;
Tel. +1-314 747-4464; Fax: +1-314 289-7009
Received: 25 June 2009; in revised form: 24 July 2009 / Accepted: 31 July 2009 /
Published: 4 August 2009
Abstract: Water-soluble, commercially-available poly(amidoamine) (PAMAM)
dendrimers are highly-branched, well-defined, monodisperse macromolecules having an
ethylenediamine core and varying surface functional groups. Dendrimers are being
employed in an increasing number of biomedical applications. In this study, commercially
obtained generation 5 hydroxyl-terminated (G
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