the hidden universal distribution of amino acid biosynthetic networks a genomic perspective on their origins and evolution氨基酸生物合成的隐藏的普遍分布网络基因组的角度来看他们的起源和演化.pdf

Volume 9, Issue 6, Article R95et al.Hernández-Montes2008 Open Access Research The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution Georgina Hernández-Montes¤*, J Javier Díaz-Mejía¤*†, Ernesto Pérez- Rueda* and Lorenzo Segovia* Addresses: *Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México. Av. Universidad, Col. Chamilpa, Cuernavaca, Morelos, México, CP 62210. †Department of Biology, Wilfrid Laurier University, University Av. Waterloo, ON N2L 3C5, Canada; and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto. College St., Toronto, ON M5S 3E1, Canada. ¤ These authors contributed equally to this work. Correspondence: Lorenzo Segovia. Email: lorenzo@ibt.unam.mx Published: 9 June 2008 Received: 4 December 2007 Revised: 6 May 2008 Genome Biology 2008, 9:R95 (doi:10.1186/gb-2008-9-6-r95) Accepted: 9 June 2008 The electronic version of this article is the complete one and can be found online at /2008/9/6/R95 © 2008 Hernández-Montes et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. parative genomics./pEvolution of amino acid biosynthesispA core of widely distributed network branches biosynthesizing at least 16 out of the 20 standard amino acids is predicted using com- Abstract Background: Twenty amino acids comprise the universal building bl