biological and structural characterization of a host-adapting amino acid in influenza virus生物学和结构表征host-adapting氨基酸的流感病毒.pdf

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus 1 2 3,4 2 2 5 Shinya Yamada , Masato Hatta , Bart L. Staker , Shinji Watanabe , Masaki Imai , Kyoko Shinya , Yuko 1 1 2,6 2 1,7 2 Sakai-Tagawa , Mutsumi Ito , Makoto Ozawa , Tokiko Watanabe , Saori Sakabe , Chengjun Li , Jin Hyun Kim2, Peter J. Myler4,8,9, Isabelle Phan4,8, Amy Raymond3,4, Eric Smith3,4, Robin Stacy4,8, Chairul A. Nidom10,11, Simon M. Lank12, Roger W. Wiseman12, Benjamin N. Bimber12, David H. O’Connor 12,13, Gabriele Neumann2, Lance J. Stewart3,4*, Yoshihiro Kawaoka1,2,5,6,7,14* 1 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 2 Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 Emerald BioStructures, Inc., Bainbridge Island, Washington, United States of America, 4 Seattle Structural Genomics Center for Infectious Disease, Washington, United States of America, 5 Department of Microbiology and Infectious Diseases, Kobe University, Hyogo, Japan, 6 Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 7 ERATO Infection-Induced Host Responses Project, Saitama, Japan, 8 Seattle Biomedical Research Institute, Seattle, Washington, United States of America, 9 Dep