spatial dynamics of human-origin h1 influenza a virus in north american swine空间动力学起源于人类h1在北美猪流感病毒.pdf

Spatial Dynamics of Human-Origin H1 Influenza A Virus in North American Swine 1 2 1 3 4 5 Martha I. Nelson *, Philippe Lemey , Yi Tan , Amy Vincent , Tommy Tsan-Yuk Lam , Susan Detmer , ´ 1 6 1,7 1,4 5 Cecile Viboud , Marc A. Suchard , Andrew Rambaut , Edward C. Holmes , Marie Gramer 1 Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Department of Microbiology and Immunology, Katholieke Universiteit Leuven, Leuven, Belgium, 3 Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, Ames, Iowa, United States of America, 4 Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, 5 The University of Minnesota Veterinary Diagnostic Laboratory, St. Paul, Minnesota, United States of America, 6 Departments of Biomathematics and Human Genetics, David Geffen School of Medicine at UCLA, and Department of Biostatistics, UCLA School of Public Health, Los Angeles, California, United States of America, 7 Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom Abstract The emergence and rapid global spread of the swine-origin H1N1/09 pandemic influenza A virus in humans underscores the importance of swine populations as reservoirs for genetically diverse influenza viruses with the potential to infect humans. However, despite their significance for animal and human health, relatively little is known about the phylogeography of swine influ