迷迭香酸对mpp 导致mes 23 5细胞损伤保护作用（Rosemary acid has protective effect on MPP on mes 23 5 cells）.doc

迷迭香酸对mpp 导致mes 23 5细胞损伤保护作用（Rosemary acid has protective effect on MPP on mes 23 5 cells） Rosemary acid has protective effect on MPP + causing mes 23.5 cell damage Article: / Author: du tingting song ning xie junxia jiang hong [abstract] objective to observe rosemary acid to 1? Methyl? 4? The protective effect of phenylpyridine cation (MPP +) on mes 23.5 cell damage. Methods four methyl azazole salt (MTT) detection method was used to observe the protective effect of the isostonic acid of different concentrations on the MPP + treated mes 23.5 cells. Results the non-toxic effect of rosemary acid on mes 23.5 cells (f = 0.581, p 0.05) was found in the results of 10-9 ~ 10-6 mol/l. MPP + of 200 mu mol/l can reduce the cell survival rate (f = 44.863, p 0.01), and the survival rate (p 0.01) can be significantly improved after using the preincubation cells of rosemary acid with 10-9 ~ 10-6 mol/l. Conclusion rosemary acid can antagonize MPP + and has a certain neuroprotective effect on the toxicity of mes 23.5 cells. [key words] rosemary acid; 1? Methyl? 4? Phenylpyridine; Mes 23.5 cells Abstract objective to investigate the neuroprotective effect of rosmarinic acid on 1? Methyl? 4? Phenylpyridinium (MPP +)? Induced damage of mes cells. 23.5 the methods determined by MTT assay was 2 observe the protection of rosmarinic acid, in the company concentrations, on MPP +? Treated mes 23.5 cell.results rosmarinic acid (10-9-10-6 mol/l) did not produce any to? Xic effect on mes 23.5 cells (f = 0.581, p 0.05). The cell viability decreased when treated with 200 mu mol/l MPP + (f = 44.863, p 0.01) by pretreatment with the 10-9-10-6 mol/l rosmarinic acid significantly elevated the cell survival rate (p 0.01). Conclusion rosmarinic acid can antagonize the toxic action of MPP + 23.5 cells on mes, possessing a certain neuroprotective effect. Key words rosmarinic acid; 1? Methyl? 4? Phenylpyridinium; Mes 23.5 cells Parkinsons disease (pd) is the second largest neurodegenerative disorder in t