the beneficial effect of vanillic acid on ulcerative colitis在溃疡性结肠炎香草酸的有益作用.pdf

Molecules 2010, 15, 7208-7217; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Beneficial Effect of Vanillic Acid on Ulcerative Colitis Su-Jin Kim 1,†, Min-Cheol Kim 2,†, Jae-Young Um 1 and Seung-Heon Hong 2,* 1 Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul 130-701, Korea; E-Mails: ksj1009@khu.ac.kr (S.-J.K); jyum@khu.ac.kr (J.-Y.U) 2 Wonkwang Oriental Medicines Research Institute, Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Korea; E-Mail: mchol@ (M.-C.K) † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: jooklim@wku.ac.kr (S.-H.H.); Tel.: +82-63-850-6805; Fax: +82-63-843-3421. Received: 1 September 2010; in revised form: 8 October 2010 / Accepted: 18 October 2010 / Published: 19 October 2010 Abstract: Vanillic acid, an oxidized form of vanillin, is a benzoic acid derivative used as a flavoring agent. The objective of this study was to determine whether vanillic acid has beneficial effects against dextran sulfate sodium (DSS)-induced ulcerative colitis. Our results showed that vanillic acid reduced the severity of the clinical signs of DSS-induced colitis, including weight loss and shortening of colon length, and the disease activity index. The results of this study showed that vanillic acid significantly suppressed the expression of cycl