decrease of peripheral and intestinal nkg2a-positive t cells in patients with ulcerative colitis减少外围和肠道nkg2a-positive t细胞在溃疡性结肠炎患者.pdf

Decrease of Peripheral and Intestinal NKG2A-Positive T Cells in Patients with Ulcerative Colitis 1,2. 1,2. 1 1¤ 2 Takehiko Katsurada , Waka Kobayashi , Utano Tomaru *, Tomohisa Baba , Shigeru Furukawa , 3 4 2 2 2,5 Akihiro Ishizu , Kazuyoshi Takeda , Naoya Sakamoto , Masahiro Asaka , Hiroshi Takeda , Masanori Kasahara1 1 Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2 Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3 Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, 4 Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 5 Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan Abstract To investigate the role of inhibitory natural killer receptors (iNKRs) in inflammatory bowel disease (IBD), we analyzed the expression of NKG2A, one of the iNKRs, on T cells in a mouse colitis model and human IBD. During the active phase of dextran sulfate sodium (DSS)-induced mouse colitis, the frequency of NKG2A+ T cells was significantly decreased in the peripheral blood, and increased in the intestine, suggesting the mobilization of this T cell subset to the sites of inflammation. Administration of anti-NKG2A antibody increased the number of inflammatory foci in DSS-induced colitis, suggesting the involvement of NKG2A+ T cells in this colitis model. In ulcerative colitis (UC) patients, the frequency of