blockage of heme oxygenase-1 abrogates the protective effect of regulatory t cells on murine pregnancy and promotes the maturation of dendritic cells堵塞的血红素oxygenase-1废除怀孕调节性t细胞在小鼠的保护作用,促进树突状细胞的成熟.pdf

Blockage of Heme Oxygenase-1 Abrogates the Protective Effect of Regulatory T Cells on Murine Pregnancy and Promotes the Maturation of Dendritic Cells 1 2 1 1 1 Anne Schumacher , Paul Ojiambo Wafula , Ana Teles , Tarek El-Mousleh , Nadja Linzke , Maria 1 1 1 2 2 Laura Zenclussen , Stefanie Langwisch , Kristina Heinze , Ivonne Wollenberg , Pablo Ariel Casalis , 2 3 1,2 Hans-Dieter Volk , Stefan Fest , Ana Claudia Zenclussen * 1 Department of Experimental Obstetrics and Gynaecology, Medical Faculty, Otto-von Guericke University of Magdeburg, Magdeburg, Germany, 2 Institute of Medical ´ ¨ Immunology, Charite, Medical University Berlin, Berlin, Germany, 3 Paediatric Oncology, Hematology and Haemostaseology, Universitatsklinikum Leipzig, Leipzig, Germany Abstract Regulatory T cells (Treg) play an important role in fetal protection. They expand during normal pregnancy and protect fetal antigens from maternal effector cells. Their effect is associated with the up-regulation of tolerance-associated molecules at the fetal-maternal interface. Among these, Heme Oxygenase-1 (HO-1, coded by Hmox1) is of special importance as its blockage correlates with increased abortion rates and its up-regulation positively affects pregnancy outcome. Here, we aimed to investigate whether the protective effect of Treg is mediated by HO-1 in a mouse model. HO-1 blockage by Zinc Protopo