teucrium plant species as natural sources of novel anticancer compounds antiproliferative, proapoptotic and antioxidant propertiesteucrium植物物种作为新型抗癌化合物抗增殖的天然来源,proapoptotic和抗氧化特性.pdf

Int. J. Mol. Sci. 2011, 12, 4190-4205; doi:10.3390/ijms OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Teucrium Plant Species as Natural Sources of Novel Anticancer Compounds: Antiproliferative, Proapoptotic and Antioxidant Properties Milan S. Stankovic 1,*, Milena G. Curcic 1, Jovana B. Zizic 1, Marina D. Topuzovic 1, 2 1 Slavica R. Solujic and Snezana D. Markovic 1 Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Str. Radoja DomanovićaNo. 12, 34000 Kragujevac, Republic of Serbia; E-Mails: milenagen@ (M.G.C.); jovanazizic@ (J.B.Z.); marina@kg.ac.rs (M.D.T.); smarkovic@kg.ac.rs (S.D.M.) 2 Department of Chemistry, Faculty of Science, University of Kragujevac, Str. Radoja Domanovića No. 12, 34000 Kragujevac, Republic of Serbia; E-Mail: ssolujic@kg.ac.rs * Author to whom correspondence should be addressed; E-Mail: mstankovic@kg.ac.rs; Tel.: +381-34-336-223; Fax: +381-34-335-040. Received: 11 April 2011; in revisedform: 3 June 2011 / Accepted: 14 June 2011 / Published: 27 June 2011 Abstract: This study deals with total phenolic content, antiproliferative and proapoptotic activity of methanolic extracts from different Teucrium species and the effect on the prooxidant/antioxidant status in HCT-116 cells. The total phenolic content of the extracts was measured spectrophotometricaly and the obtained results r