synthesis and biological activity of new 1,3-dioxolanes as potential antibacterial and antifungal compounds合成和生物活性的新1,3-dioxolanes作为潜在的抗菌和抗真菌的化合物.pdf

Molecules 2011, 16, 6806-6815; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds Hatice Başpınar Küçük 1, Ayşe Yusufoğlu 1,*, Emel Mataracı 2 and Sibel Döşler 2 1 Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey 2 Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, 34116 Bayezit, Istanbul, Turkey * Author to whom correspondence should be addressed; E-Mail: ayseserg@.tr; Tel.: +90-212-473-70-30; Fax: +90-212-473-71-90. Received: 20 July 2011; in revised form: 2 August 2011 / Accepted: 3 August 2011 / Published: 10 August 2011 Abstract: A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity