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synthesis of novel azo schiff bases and their antibacterial and antifungal activities合成的新型偶氮希夫碱及其抗菌和抗真菌的活动.pdf

发布：2017-09-07约3.55万字共10页下载文档

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Molecules 2004, 9, 815-824 molecules ISSN 1420-3049 Synthesis of Novel Azo Schiff Bases and Their Antibacterial and Antifungal Activities A. A. Jarrahpour 1,*, M. Motamedifar 2, K. Pakshir 3, N. Hadi 2 and M. Zarei 1 1 Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. Tel.: (+98) 711 2284822, Fax: (+98) 711 2280926. 2 Department of Bacteriology and Virology, Shiraz Medical School, Shiraz University Medical Science, Shiraz 71345, Iran. 3 Department of Parasitology and Mycology, Shiraz Medical School, Shiraz University Medical Science, Shiraz 71345, Iran. * Author to whom correspondence should be addressed; E-mail: aliasghar6683@ or jarrah@chem.susc.ac.ir Received: 19 January 2004 / Accepted: 26 February 2004 / Published: 30 September 2004 Abstract: Ten new azo Schiff bases 5a-h and 7a-b were prepared in excellent yields via the condensation of different aromatic amines and a new azoaldehyde, 2-hydroxy-3- methoxy-5-(4-methoxyphenylazo)benzaldehyde (4) by two different methods. All new compounds were tested against five microorganisms: Staphylococcus aureus (Gram positive and methicillin resistant), Bacillus subtilis (Gram positive), Kelebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli (all Gram negative). Compounds 4, 5a, 5c, 5d and 5g were moderately active against Staphylococcus aureus and Bacillus subtilis . Compound 7b was highly active against Bacillus subtilis

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