synthesis, characterization, acetylcholinesterase inhibition, molecular modeling and antioxidant activities of some novel schiff bases derived from 1-(2-ketoiminoethyl)piperazines合成、表征、乙酰胆碱酯酶抑制作用,一些新奇的希夫碱的分子建模和抗氧化活动来自1 -(2-ketoiminoethyl)哌嗪类.pdf

Molecules 2011, 16, 9316-9330; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Characterization, Acetylcholinesterase Inhibition, Molecular Modeling and Antioxidant Activities of Some Novel Schiff Bases Derived from 1-(2-Ketoiminoethyl)piperazines Saleh M. Salga 1,*, Hapipah M. Ali 1, Mahmood A. Abdullah 2, Siddig I. Abdelwahab 3,*, 4 3 3 1 Lam Kok Wai , Michael J. C. Buckle , Sri Devi Sukumaran and A. Hamid A. Hadi 1 Department of Chemistry, University of Malaya, Kuala Lumpur, 50603, Malaysia 2 Department of Molecular Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia 3 Department of Pharmacy, University of Malaya, Kuala Lumpur, 50603, Malaysia 4 Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia * Author to whom correspondence should be addressed; E-Mail: salgamohd@ (S.M.S.); siddigroa@.my (S.I.A.); Tel.: +60126565990; Fax: +60379694906. Received: 2 August 2011; in revised form: 22 October 2011 / Accepted: 24 October 2011 / Published: 7 November 2011 Abstract: Some novel Schiff bases derived from 1-(2-ketoiminoethyl)piperazines were synthesized and characterized by mass spectroscopy, FTIR, UV-Visible, 1H and 13C-NMR. The compounds were tested for inhibitory activities on human acetylcholinesterase (hAChE), antioxidant activities, acute oral toxicity and further studied by molecular