synthesis, characterization and biological studies of some novel thieno[2,3-d]pyrimidines的合成、表征和生物研究一些新奇thieno[2,3 - d]嘧啶.pdf

Molecules 2010, 15, 3932-3957; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines Khulud M. Al-Taisan 1,*, Hassan M. A. Al-Hazimi 2 and Shar S. Al-Shihry 1 1 Chemistry Department, College of Science, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi Arabia 2 Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia * Author to whom correspondence should be addressed; E-Mail: Kaltisan@. Received: 29 March 2010; in revised form: 20 May 2010 / Accepted: 27 May 2010 / Published: 1 June 2010 Abstract: Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2- aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo- thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined. Keywords: thienopyridines; triazolothienopyrimidines; antibacterial activity; cytotoxic activity 1. Introduction Heterocycles containing the thienopyrimidine moiety (Figure 1) are of interest because of their interesting pharmacological and biological