synthesis, characterization, anti-inflammatory and in vitro antimicrobial activity of some novel alkylaryl substituted tertiary alcohols合成、表征、消炎和体外抗菌活性的新型烷基芳基取代叔醇.pdf

Molecules 2011, 16, 10337-10346; doi:10.3390/molecules161210337 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols Muhammad Baseer 1, Farzana Latif Ansari 1, Zaman Ashraf 2,* and Rafiuzzaman SaeedulHaq 3 1 Department of Chemistry, Quaid-i-azam University, Islamabad 45320, Pakistan 2 Department of Chemistry, Allam Iqbal Open University, Islamabad 44000, Pakistan 3 Riphah Institute of Pharmaceutical Sciences, Islamabad 44000, Pakistan * Author to whom correspondence should be addressed; E-Mail: mzchem@. Received: 20 November 2011; in revised form: 5 December 2011/ Accepted: 6 December 2011 / Published: 14 December 2011 Abstract: The synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents to afford alkyl/aryl substituted tertiary alcohols 1-10. The structures of the synthesized compounds were assigned on the basis of FT-IR, 1H-NMR, 13C-NMR and mass spectroscopic data. The in vivo anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced hind paw edema method and was compared with that of ibuprofen. Some of the newly synthesized