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synthesis and biological activity of some 3-(4-(substituted)-piperazin-1-yl)cinnolines合成和生物活性的3 -(4 -(取代)-piperazin-1-yl)噌啉.pdf

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Molecules 2012, 17, 227-239; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Biological Activity of Some 3-(4-(Substituted)- piperazin-1-yl)cinnolines 1 1 2 3 4 Eman D. Awad , Mustafa M. El-Abadelah , Suzan Matar , Malek A. Zihlif , Randa G. Naffa , Ehab Q. Al-Momani 5 and Mohammad S. Mubarak 1,†,* 1 Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan 2 Department of Biological Sciences, Faculty of Science, The University of Jordan, Amman 11942, Jordan 3 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan 4 Laboratory of Molecular Biology Research, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan 5 Clinic of Nuclear Medicine, Ulm University, Ulm 89081, Germany † Present address: Al-Ghad International Colleges of Health Sciences, P.O. Box 2174, Riyadh 11451, Saudi Arabia. * Author to whom correspondence should be addressed; E-Mail: mmubarak@.jo; Tel.: +96-26-535-5000 Ext. 22021; Fax: +96-26-530-0253. Received: 15 November 2011; in revised form: 21 December 2011 / Accepted: 22 December 2011 / Published: 28 December 2011 Abstract: A new series of 6-substituted-4-methyl-3-(4-arylpiperazin-1-yl)cinnolines 8–10 were synthesized as potential antifungal agents via intramolecular cyclization of the respective 1-(2-arylhydrazono)-1-(4-arylpiperazin
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