synthesis, characterization and antileucemic activity of 7-hydroxy-8-acetylcoumarin benzoylhydrazone的合成、表征、活性antileucemic 7-hydroxy-8-acetylcoumarin benzoylhydrazone.pdf

Molbank 2008, M574 OPEN ACCESS molbank ISSN 1422-8599 /molbank Short Note Synthesis, Characterization and Antileucemic Activity of 7-Hydroxy-8-acetylcoumarin Benzoylhydrazone Antigoni Kotali 1,*, Ioannis S. Lafazanis, Athanassios Papageorgiou 2, Eleni Chrysogelou 2, 3 4 Theodoros Lialiaris , and Zacharias Sinakos 1 Laboratory of Organic Chemistry, Department of Chemical Engineering, College of Engineering, University of Thessaloniki, Thessaloniki 54006, Greece E-mail: kotali@eng.auth.gr 2 Department of Experimental Chemotherapy, Symeonidion Research Center, Theagenion Cancer Hospital, Thessaloniki 54007, Greece 3 Department of Genetics, Democritus University of Thrace, Alexandroupolis, Greece 4 EKETA, Thessaloniki 57001, Greece * Author to whom correspondence should be addressed. Received: 24 April 2007; in revised form: 8 August 2008 / Accepted: 18 August 2008 / Published: 24 August 2008 Keywords: 7-Hydroxy-8-acetylcoumarin, benzoic hydrazide. As part of a research programme targeting novel molecules derived from nitrogen derivatives of o- hydroxyaryl ketones [1] we synthesised 7-hydroxy-8-acetylcoumarin benzoylhydrazone. Coumarins are very well known for their biological activity [2]. Moreover hydrazone moiety has been reported to possess anticancer activity [3]. Thus, it is not unreasonable to assume that a molecule that possesses both coumarin and hydrazone features will possibly show interesting combined biological activity. PhCONHN