biotransformations utilizing β-oxidation cycle reactions in the synthesis of natural compounds and medicines生物转化利用β-oxidation循环反应的合成天然化合物和药物.pdf

Int. J. Mol. Sci. 2012, 13, 16514-16543; doi:10.3390/ijms131216514 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Biotransformations Utilizing β-Oxidation Cycle Reactions in the Synthesis of Natural Compounds and Medicines Alina Świzdor *, Anna Panek, Natalia Milecka-Tronina and Teresa Kołek Department of Chemistry, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland; E-Mails: anna.szpineter@up.wroc.pl (A.P.); ecka@ (N.M.-T.); teresa.kolek@interia.pl (T.K.) * Author to whom correspondence should be addressed; E-Mail: alina.swizdor@up.wroc.pl; Tel.: +48-71-3205-252; Fax: +48-71-3284-124. Received: 31 August 2012; in revised form: 19 November 2012 / Accepted: 21 November 2012 / Published: 5 December 2012 Abstract: β-Oxidation cycle reactions, which are key stages in the metabolism of fatty acids in eucaryotic cells and in processes with a significant role in the degradation of acids used by microbes as a carbon source, have also found application in biotransformations. One of the major advantages of biotransformations based on the β-oxidation cycle is the possibility to transform a substrate in a series of reactions catalyzed by a number of enzymes. It allows the use of sterols as a substrate base in the production of natural steroid compounds and their analogues. This route also leads to biologically active compounds of