recent advances in the synthesis of n-containing heteroaromatics via heterogeneously transition metal catalysed cross-coupling reactions合成的最新进展n-containing杂芳族化合物通过不均匀对过渡金属催化的交叉耦合反应.pdf

Molecules 2011, 16, 5241-5267; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Recent Advances in the Synthesis of N-Containing Heteroaromatics via Heterogeneously Transition Metal Catalysed Cross-Coupling Reactions Laurent Djakovitch *, Nelly Batail and Marie Genelot Institut de Recherches sur la Catalyse et l’Environnement de Lyon (IRCELYON), Université de Lyon, CNRS, UMR 5256, 2 avenue Albert Einstein, Villeurbanne F-69626, France * Author to whom correspondence should be addressed; E-Mail: Laurent.Djakovitch@ircelyon.univ-lyon1.fr; Tel.: +33-47244-5381; Fax: +33-47244-5399. Received: 31 May 2011; in revised form: 20 June 2011 / Accepted: 21 June 2011 / Published: 23 June 2011 Abstract: N-containing heteroaromatics are important substructures found in numerous natural or synthetic alkaloids. The diversity of the structures encountered, as well as their biological and pharmaceutical relevance, have motivated research aimed at the development of new economical, efficient and selective synthetic strategies to access these compounds. Over more than 100 years of research, this hot topic has resulted in numerous so-called “classical synthetic methods” that have really contributed to this important area. However, when the selective synthesis of highly functional heteroaromatics like indoles, quinolones, indoxyls, etc. is considered these methods remain limited. Recently transition metal-catalysed (TM-catalysed) pr