文档详情

synthesis, dna-binding and antiproliferative properties of acridine and 5-methylacridine derivatives吖啶的合成、dna结合蛋白和抗增殖特性和5-methylacridine衍生品.pdf

发布：2017-09-10约6万字共16页下载文档

文本预览下载声明

Molecules 2012, 17, 7067-7082; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, DNA-Binding and Antiproliferative Properties of Acridine and 5-Methylacridine Derivatives Rubén Ferreira 1,2, Anna Aviñó 1,2, Stefania Mazzini 3 and Ramon Eritja 1,2,* 1 Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, E-08028 Barcelona, Spain; E-Mails: ruben.ferreira@ (R.F.); anna.avinyo@ (A.A.) 2 Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Jordi Girona 18, E-08034 Barcelona, Spain 3 Department of Agro-Food Molecular Sciences (DISMA), University of Milan, Via Celoria 2, 20133 Milan, Italy; E-Mail: stefania.mazzini@unimi.it * Author to whom correspondence should be addressed; E-Mails: recgma@cid.csic.es or ramon.eritja@; Tel.: +34-93-403-9942; Fax: +34-93-204-5904. Received: 8 May 2012; in revised form: 24 May 2012 / Accepted: 4 June 2012 / Published: 8 June 2012 Abstract: Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4- carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by competitive dialysis and compared with the anti-proliferative activities. While inactive acridine derivatives showed high selectivity for G-quadruplex structures, the most active 5-methylacridine-4-carboxamide derivatives had high affinity for DNA but

显示全部

相似文档

synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents合成和药理筛选一些芳酰基和heteroaroyl selenylacetic酸衍生品作为细胞毒性和抗增殖剂.pdf Molecules 2009, 14, 3313-3338; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-07 约10.11万字 26页立即下载
synthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives合成和新8-nitrofluoroquinolone衍生品的抗菌性能.pdf Molecules 2007, 12, 1240-1258 molecules ISSN 1420-3049
2017-09-10 约7.94万字 19页立即下载
synthesis, molecular properties prediction, and anti-staphylococcal activity of n-acylhydrazones and new 1,3,4-oxadiazole derivatives合成、分子特性预测,anti-staphylococcal n-acylhydrazones和新活动1,3,则对衍生品.pdf Molecules 2012, 17, 5095-5107; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-09 约5.29万字 13页立即下载
synthesis, characterization, and photovoltaic properties of soluble tiopc derivatives合成、表征和可溶性tiopc光伏性质的衍生品.pdf Int. J. Mol. Sci. 2008, 9, 2745-2756; DOI: 10.3390/ijms9122745 OPEN ACCESS International Journal of
2017-09-07 约3.52万字 12页立即下载
synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives合成、光谱特性和antipathogenic活动新的硫脲衍生物.pdf Molecules 2011, 16, 7593-7607; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-11 约字 15页立即下载
synthesis, molecular structure and spectral properties of quaternary ammonium derivatives of 1,1-dimethyl-1,3-propylenediamine季铵的合成、分子结构和光谱性质的衍生品,1-dimethyl-1 3-propylenediamine.pdf Molecules 2008, 13, 379-390 molecules ISSN 1420-3049
2017-09-10 约字 12页立即下载
synthesis, characterization and photophysical properties of pyridine-carbazole acrylonitrile derivatives的合成、表征及光物理性能pyridine-carbazole丙烯腈衍生品.pdf Materials 2011, 4, 562-574; doi:10.3390/ma4030562 OPEN ACCESS materials
2017-09-09 约4.82万字 13页立即下载
synthesis and biological activity of peptide derivatives of iodoquinazolinonesnitroimidazoles的合成和生物活性肽iodoquinazolinonesnitroimidazoles的衍生品.pdf Molecules 2008, 13, 958-976 molecules ISSN 1420-3049
2017-09-10 约字 19页立即下载
synthesis and antiproliferative activity of ammonium and imidazolium ionic liquids against t98g brain cancer cells合成和抗增殖活性和imidazolium铵离子液体对t98g脑癌细胞.pdf Molecules 2012, 17, 13727-13739; doi:10.3390/molecules171213727 OPEN ACCESS molecules
2017-09-09 约3.87万字 13页立即下载
synthesis of new pyrazole and pyrimidine steroidal derivatives新吡唑并嘧啶的合成甾族的衍生品.pdf Molecules 2003, 8, 444-452 molecules ISSN 1420-3049
2017-09-09 约2.93万字 9页立即下载
synthesis of n-substituted acridinediones and polyhydroquinoline derivatives in refluxing water合成n - acridinediones和polyhydroquinoline衍生品在回流水.pdf Molecules 2012, 17, 5339-5345; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-09 约2.81万字 7页立即下载
synthesis, reactions and antimicrobial activities of 8-ethoxycoumarin derivatives的合成、反应和抗菌活动8-ethoxycoumarin衍生品.pdf Molecules 2012, 17, 971-988; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-10 约6.56万字 18页立即下载
synthesis, characterization and cytotoxicity of new rotundic acid derivatives合成、表征和细胞毒性的新rotundic酸衍生品.pdf Molecules 2012, 17, 1278-1291; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-11 约6.54万字 14页立即下载
synthesis and antiangiogenic activity of novel gambogic acid derivatives新藤黄酸的合成和抗血管新生活动衍生品.pdf Molecules 2012, 17, 6249-6268; doi:10.3390/molecule OPEN ACCESS molecules
2017-09-08 约7.29万字 20页立即下载
synthesis and analgesic activity evaluation of some agmatine derivatives合成和镇痛活性评价的胍基丁胺衍生品.pdf Molecules 2006, 11, 393-402 molecules ISSN 1420-3049
2017-09-09 约3.63万字 10页立即下载