the antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of rhodiola sachalinensis a. bor酚类化合物的抗氧化和抗炎作用分离红景天sachalinensis a bor的根源.pdf

Molecules 2012, 17, 11484-11494; doi:10.3390/molecules171011484 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR Kang In Choe, Joo Hee Kwon, Kwan Hee Park, Myeong Hwan Oh, Manh Heun Kim, Han Hyuk Kim, Su Hyun Cho, Eun Kyung Chung, Sung Yi Ha and Min Won Lee * College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea * Author to whom correspondence should be addressed; E-Mail: mwlee@cau.ac.kr; Tel.: +82-2-820-5602; Fax: +82-2-822-9778. Received: 4 July 2012; in revised form: 28 August 2012 / Accepted: 21 September 2012 / Published: 27 September 2012 Abstract: Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (1), salidroside (2), multiflorin B (3), kaempferol-3,4′-di-O-β-D-glucopyranoside (4), afzelin (5), kaempferol (6), rhodionin (7), and rhodiosin (8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity. Keywords: Rhodiola sachalinensis ; antio