testing the neutral theory of molecular evolution using genomic data a comparison of the human and bovine transcriptome测试使用基因分子进化中性理论比较人类和牛转录组的数据.pdf

Genet. Sel. Evol. 38 (2006) 321–341 321 c INRA, EDP Sciences, 2006 DOI: 10.1051/gse:2006007 Original article Testing the neutral theory of molecular evolution using genomic data: a comparison of the human and bovine transcriptome a,b ∗ c a Sean ME , John ME , Andrew M , Alan M c b a,d C , Paul S , Mike G a Primary Industries Research Victoria, Animal Genetics and Genomics, Attwood VIC 3049, Australia b Latrobe University, Department of Genetics, Bundoora VIC 3086, Australia c AgResearch, Department of Genetics, Private Bag 50034, Mosgiel, New Zealand d Melbourne University, School of Agriculture and Food Systems, Melbourne VIC 3000, Australia (Received 31 August 2005; accepted 8 December 2005) Abstract – Despite growing evidence of rapid evolution in protein coding genes, the contribu- tion of positive selection to intra- and interspecific differences in protein coding regions of the genome is unclear. We attempted to see if genes coding for secreted proteins and genes with narrow expression, specifically those preferentially expressed in the mammary gland, have di-