comparative genomics of gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential鞘突加德纳菌属菌株的比较基因组学揭示了大量不同的代谢和毒性的潜力.pdf

Comparative Genomics of Gardnerella vaginalis Strains Reveals Substantial Differences in Metabolic and Virulence Potential 1 1 1 2 2 Carl J. Yeoman , Suleyman Yildirim , Susan M. Thomas , A. Scott Durkin , Manolito Torralba , Granger 2 3 3 3 3 3 Sutton , Christian J. Buhay , Yan Ding , Shannon P. Dugan-Rocha , Donna M. Muzny , Xiang Qin , 3 4 4 1,5 3,6 Richard A. Gibbs , Steven R. Leigh , Rebecca Stumpf , Bryan A. White , Sarah K. Highlander , Karen E. Nelson2, Brenda A. Wilson1,7* 1 Institute for Genomic Biology, University of Illinois, Urbana, Illinois, United States of America, 2 J. Craig Venter Institute, Rockville, Maryland, United States of America, 3 Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America, 4 Department of Anthropology, University of Illinois, Urbana, Illinois, United States of America, 5 Department of Animal Sciences, University of Illinois, Urbana, Illinois, United States of America, 6 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, 7 Department of Microbiology, University of Illinois, Urbana, Illinois, United States of America Abstract Background: Gardnerella vaginalis is described as a common vaginal bacterial species whose presence correlates strongly with bacterial vaginosis (BV). Here we report the genome sequencing and comparative analyses of three strains of G. vaginalis. Strains 317 (A