comparative genomics and transcriptomics of propionibacterium acnes比较基因组学和转录组的丙酸菌属曼秀雷敦.pdf

Comparative Genomics and Transcriptomics of Propionibacterium acnes 1 2 1 ¨ 1 ¨ 1 Elzbieta Brzuszkiewicz , January Weiner , Antje Wollherr , Andrea Thurmer , Jennifer Hupeden , Hans B. 3 3 1 1 4 Lomholt , Mogens Kilian , Gerhard Gottschalk , Rolf Daniel , Hans-Joachim Mollenkopf , Thomas F. 5 ¨ 5 Meyer , Holger Bruggemann * ¨ ¨ ¨ 1 Gottingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University of Gottingen, Gottingen, Germany, 2 Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany, 3 Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark, 4 Core Facility Microarray, Max Planck Institute for Infection Biology, Berlin, Germany, 5 Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany Abstract The anaerobic Gram-positive bacterium Propionibacterium acnes is a human skin commensal that is occasionally associated with inflammatory diseases. Recent work has indicated that evolutionary distinct lineages of P. acnes play etiologic roles in disease while others are associated with maintenance of skin homeostasis. To shed light on the molecular basis for differential strain properties, we carried out genomic and transcriptomic analysis of distinct P. acnes strains. We sequenced the genome of the P. acnes strain 266, a type I-1a strain. Comparative genome analysis of strain 266 and four other P. acnes strains revealed that overall gen