comparative genomics of 2009 seasonal plague (yersinia pestis) in new mexico比较基因组学2009年季节性瘟疫(鼠疫杆菌)在新墨西哥州.pdf

Comparative Genomics of 2009 Seasonal Plague (Yersinia pestis) in New Mexico 1 1,5. 1,2.¤a 1. 3 Henry S. Gibbons *, Michael D. Krepps , Gary Ouellette , Mark Karavis , Lisa Onischuk , Pascale 3 1 1 1 1,2¤b 4 Leonard , Stacey Broomall , Todd Sickler , Janet L. Betters , Paul McGregor , Greg Donarum , Alvin 4 4 1¤c 1 1¤d Liem , Ed Fochler , Lauren McNew , C. Nicole Rosenzweig , Evan Skowronski 1 United States Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, United States of America, 2 Science Applications International Corporation, Aberdeen Proving Ground, Maryland, United States of America, 3 New Mexico Department of Public Health, Albuquerque, New Mexico, United States of America, 4 OptiMetrics, Inc., Abingdon, Maryland, United States of America, 5 Excet, Inc., Springfield, Virginia, United States of America Abstract Plague disease caused by the Gram-negative bacterium Yersinia pestis routinely affects animals and occasionally humans, in the western United States. The strains native to the North American continent are thought to be derived from a single introduction in the late 19th century. The degree to which these isolates have diverged genetically since their introduction is not clear, and new genomic markers to assay the diversity of North American plague are highly desired. To assay genetic diversity of plague is