comparative genomics of the mating-type loci of the mushroom flammulina velutipes reveals widespread synteny and recent inversions比较基因组学的交配型基因座蘑菇菇中孢子揭示广泛的同线性和最近的反演.pdf

Comparative Genomics of the Mating-Type Loci of the Mushroom Flammulina velutipes Reveals Widespread Synteny and Recent Inversions 1 1 1 1 1 Arend F. van Peer , Soon-Young Park , Pyung-Gyun Shin , Kab-Yeul Jang , Young-Bok Yoo , Young-Jin 2 2 1 3 1 Park , Byoung-Moo Lee , Gi-Ho Sung , Timothy Y. James , Won-Sik Kong * 1 Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Suwon, Republic of Korea, 2 National Academy of Agricultural Science, Rural Development Administration, Suwon, Republic of Korea, 3 Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America Abstract Background: Mating-type loci of mushroom fungi contain master regulatory genes that control recognition between compatible nuclei, maintenance of compatible nuclei as heterokaryons, and fruiting body development. Regions near mating-type loci in fungi often show adapted recombination, facilitating the generation of novel mating types and reducing the production of self-compatible mating types. Compared to other fungi, mushroom fungi have complex mating-type systems, showing both loci with redundant function (subloci) and subloci with many alleles. The genomic organization of mating-type loci has been solved in very few mushroom species, which complicates proper interpretation of mating-type evolution and use of those genes in breeding programs. Methodology/Principal Findings: We report a complete genetic structure of the mating-type loci from the tetrapolar, edible mushroom Flammulina velutipes mating type A3B3