the complete genome sequence of fibrobacter succinogenes s85 reveals a cellulolytic and metabolic specialist的完整基因组序列fibrobacter succinogenes s85揭示了纤维素分解和代谢专家.pdf

The Complete Genome Sequence of Fibrobacter succinogenes S85 Reveals a Cellulolytic and Metabolic Specialist 1,2 3 3 1,2 4 4 Garret Suen , Paul J. Weimer , David M. Stevenson , Frank O. Aylward , Julie Boyum , Jan Deneke , 4 5 5 6 5,6 Colleen Drinkwater , Natalia N. Ivanova , Natalia Mikhailova , Olga Chertkov , Lynne A. Goodwin , Cameron R. Currie1,2, David Mead1,4, Phillip J. Brumm1,7* 1 DOE Great Lakes Bioenergy Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 US Dairy Forage Research Center, U.S. Department of Agriculture-Agricultural Research Services (USDA-ARS), Madison, Wisconsin, United States of America, 4 Lucigen Corporation, Middleton, Wisconsin, United States of America, 5 DOE Joint Genome Institute, Walnut Creek, California, United States of America, 6 Biosciences Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, 7 C5–6 Technologies, Middleton, Wisconsin, United States of America Abstract Fibrobacter succinogenes is an important member of the rumen microbial community that converts plant biomass into nutrients usable by its host. This bacterium, which is also one of only two cultivated species in its phylum, is an efficient and prolific degrader of cellulose. Specifically, it has a particularly high activity against crystalline cellulose that requires close