complete genome sequence of treponema paraluiscuniculi, strain cuniculi a the loss of infectivity to humans is associated with genome decay梅毒paraluiscuniculi的完整基因组序列,应变cuniculi人类传染性的损失与基因组衰变.pdf

Complete Genome Sequence of Treponema paraluiscuniculi, Strain Cuniculi A: The Loss of Infectivity to Humans Is Associated with Genome Decay ˇ 1 ´ ´ 1 1 ˇ ´ 1 2 David Smajs *, Marie Zobanıkova , Michal Strouhal , Darina Cejkova , Shannon Dugan-Rocha , Petra ´ˇ ´ 1 3 4 2 5 2 Pospısilova , Steven J. Norris , Tom Albert , Xiang Qin , Kym Hallsworth-Pepin , Christian Buhay , 2 2,5 2 2,5 Donna M. Muzny , Lei Chen , Richard A. Gibbs , George M. Weinstock 1 Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic, 2 Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America, 3 Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America, 4 NimbleGen Systems, Inc., Madison, Wisconsin, United States of America, 5 The Genome Sequencing Center, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America Abstract Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategie