smoking and nicotine exposure delay development of collagen-induced arthritis in mice吸烟和尼古丁暴露延缓小鼠胶原诱导关节炎的发展.pdf

Available online /content/11/3/R88 Vol 11 No 3 Open Access Research article Smoking and nicotine exposure delay development of collagen-induced arthritis in mice 1 1,2 1 2 1 Sofia S Lindblad *, Piotr Mydel *, Ing-Marie Jonsson , Robert M Senior , Andrej Tarkowski and Maria Bokarewa1 1Department of Rheumatology and Inflammation Research, University of Gothenburg, Sahlgrenska University Hospital, Guldhedsgatan 10, Göteborg, S-41346, Sweden 2Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University, 660 S. Euclid Avenue, Campus Box 8052 St. Louis, Missouri 63110, USA * Contributed equally Corresponding author: Sofia S Lindblad, sofia.lindblad@rheuma.gu.se Received: 25 Feb 2009 Revisions requested: 30 Mar 2009 Revisions received: 8 Jun 2009 Accepted: 11 Jun 2009 Published: 11 Jun 2009 Arthritis Research Therapy 2009, 11:R88 (doi:10.1186/ar2728) This article is online at: /content/11/3/R88 © 2009 Lindblad et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Recent epidemiologic studies have implicated controls (P 0.05). Histologic index and weight changes were smoking as an environmental risk factor for the development of comparable between the groups; however, smoking mice rheumatoid arthritis (RA). The aim of the present