deficiency of antinociception and excessive grooming induced by acute immobilization stress in per1 mutant mice镇痛效应不足和过度修饰引起的急性固定压力per1突变小鼠.pdf

Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice 1,2 3 4 5 1 1 1 Jing Zhang , Zhouqiao Wu , Linglin Zhou , Huili Li , Huajing Teng , Wei Dai , Yongqing Wang , Zhong Sheng Sun1* 1 Behavioral Genetics Centre, Institute of Psychology, Chinese Academy of Sciences, Beijing, People’s Republic of China, 2 Graduate University of Chinese Academy of Sciences, Beijing, People’s Republic of China, 3 Peking University Third Hospital, Peking University Health Science Center, Beijing, People’s Republic of China, 4 Institute of Genomic Medicine, Wenzhou Medical College, Wenzhou, Zhejiang, People’s Republic of China, 5 Capital Institute of Pediatrics, Beijing, People’s Republic of China Abstract Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary- adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced reactions. Corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) and corticosterone are considered as molecular markers for stress-induced grooming behavior. Oxytocin in PVN is an essential modulator for stress- induced antinociception. The clock gene, Per1, has been identified as an effecter response to the acute stresses, but its function in neuroendocrine stress systems remains unclear. In the present study we observed the alterations in grooming and nociceptive behaviors induced by acute immobilization stress in Per1 mutant mice and other genotypes (wild types and Per2 mutant). The results displayed that stress elicited a more robust effect on grooming behavior in Per1 mutant mice than i