zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patientszinc-alpha 2-glycoprotein基因表达与胰岛素抵抗和分解脂肪的脂肪组织相关基因在病态肥胖患者.pdf

Zinc-Alpha 2-Glycoprotein Gene Expression in Adipose Tissue Is Related with Insulin Resistance and Lipolytic Genes in Morbidly Obese Patients ´ 1 . ´ 2,3 . ´ ´ 3,4 ´ 1 Lourdes Garrido-Sanchez * , Eduardo Garcıa-Fuentes * , Diego Fernandez-Garcıa , Xavier Escote , Juan Alcaide2,4, Pablo Perez-Martinez3,5, Joan Vendrell 1, Francisco J. Tinahones3,4 ´ ´ ´ 1 CIBERDEM, Hospital Universitari Joan XXIII, Pere Virgili Institute, Tarragona, Spain, 2 Fundacion IMABIS, Malaga, Spain, 3 Ciber Fisiopatologıa Obesidad y Nutricion ´ ´ ´ (CIBEROBN), Malaga, Spain, 4 Servicio de Endocrinologıa y Nutricion, Hospital Clınico Virgen de la Victoria, Malaga, Spain, 5 Servicio de Medicina Interna, Hospital ´ Universitario Reina Sofia, Cordoba, Spain Abstract Objective: Zinc-a2 glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). Methods: mRNA expression levels of PPARc, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patie